Tuberstemonine

Names

[ Name ]:
Tuberstemonine

[Synonym ]:
(2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl]dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
TuberosteMonin
Tuberstemonine
Azepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one, 8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-, (2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-
(2S,7aR,8R,8aS,11S,11aS,11bR,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4-methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one

Biological Activity

[Description]:

Tuberstemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR)[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Pudjiastuti P, et al. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP⁺ Reductase from Malaria Parasites. J Parasitol Res. 2018 Aug 26;2018:3469132.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
554.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₃NO₄

[ Molecular Weight ]:
375.502

[ Flash Point ]:
289.0±30.1 °C

[ Exact Mass ]:
375.240967

[ PSA ]:
55.84000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.556

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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