Echitamine chloride

Names

[ Name ]:
Echitamine chloride

Biological Activity

[Description]:

Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 µM[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

IC50: 10.92 µM (Pancreatic lipase)[2]

[References]

[1]. Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57(9):1213-9.

[2]. Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₉ClN₂O₄

[ Molecular Weight ]:
385.47700

[ Exact Mass ]:
385.21300

[ PSA ]:
78.79000

[ LogP ]:
1.48570

Related Compounds

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