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ARM-1

Names

[ CAS No. ]:
68729-05-5

[ Name ]:
ARM-1

[Synonym ]:
4-(4-Benzylphenyl)-1,3-thiazol-2-amine
2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-

Biological Activity

[Description]:

ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase

[References]

[1]. El-Naggar MH, et al. Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy. Bioorg Med Chem. 2017;25(3):1277-1285.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
462.7±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H14N2S

[ Molecular Weight ]:
266.361

[ Flash Point ]:
233.6±22.9 °C

[ Exact Mass ]:
266.087769

[ LogP ]:
4.13

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.660

Related Compounds