eupatoriopicrine

Names

[ Name ]:
eupatoriopicrine

[Synonym ]:
6α-[Hydroxy-8β-(4-Hydroxy-2-hydroxymethyl-trans-crotonoyloxy)-germacra-1(10)t,4t,11(13)-trien-12-saeure-6-lacton
(E)-4-Hydroxy-2-hydroxymethyl-but-2-enoic acid (6E,10E)-(3aR,4R,11aR)-6,10-dimethyl-3-methylene-2-oxo-2,3,3a,4,5,8,9,11a-octahydro-cyclodeca[b]furan-4-yl ester
6α-[hydroxy-8β-(4-hydroxy-2-hydroxymethyl-trans-crotonoyloxy)-germacra-1(10)t,4t,11(13)-trien-12-oic acid-6-lactone

Biological Activity

[Description]:

Eupatoriopicrin is an antitrypanosomic agent with an IC50 value of 1.2 μM (T. b. rhodesiense). Eupatoriopicrin is cytotoxic to L6 cells with an IC50 value of 1.6 μM[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Julianti T, et a. Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia. 2011 Oct;82(7):955-9.

Chemical & Physical Properties

[ Density]:
1.1481 (rough estimate)

[ Boiling Point ]:
414.03°C (rough estimate)

[ Molecular Formula ]:
C₂₀H₂₆O₆

[ Molecular Weight ]:
362.42

[ Exact Mass ]:
362.17300

[ PSA ]:
93.06000

[ LogP ]:
1.98350

[ Index of Refraction ]:
1.4450 (estimate)