GSK 264220A

Names

[ Name ]:
GSK 264220A

[Synonym ]:
Urea, N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-
1-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furyl]-3-phenylurea
1-[2-Methyl-5-(piperidin-1-ylsulfonyl)-3-furyl]-3-phenylurea
N-[2-methyl-5-(piperidinosulfonyl)-3-furyl]-N'-phenylurea

Biological Activity

[Description]:

GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Keller PM, et al. A high-throughput screen for endothelial lipase using HDL as substrate. J Biomol Screen. 2008 Jul;13(6):468-75.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₂₁N₃O₄S

[ Molecular Weight ]:
363.431

[ Exact Mass ]:
363.125275

[ PSA ]:
100.03000

[ LogP ]:
2.01

[ Index of Refraction ]:
1.633

GSK 264220A

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds