GSK 264220A

Names

[ Name ]:
GSK 264220A

[Synonym ]:
Urea, N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-
1-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furyl]-3-phenylurea
1-[2-Methyl-5-(piperidin-1-ylsulfonyl)-3-furyl]-3-phenylurea
N-[2-methyl-5-(piperidinosulfonyl)-3-furyl]-N'-phenylurea

Biological Activity

[Description]:

GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Keller PM, et al. A high-throughput screen for endothelial lipase using HDL as substrate. J Biomol Screen. 2008 Jul;13(6):468-75.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₂₁N₃O₄S

[ Molecular Weight ]:
363.431

[ Exact Mass ]:
363.125275

[ PSA ]:
100.03000

[ LogP ]:
2.01

[ Index of Refraction ]:
1.633

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.