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Kuwanon E

Names

[ CAS No. ]:
68401-05-8

[ Name ]:
Kuwanon E

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(5-((2E)-3,7-dimethyl-2,6-octadienyl)-2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2S)-
4H-1-Benzopyran-4-one, 2-[5-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl]-2,3-dihydro-5,7-dihydroxy-, (2S)-
(2S)-2-{5-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl}-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

Kuwanon E shows cytotoxic activity against THP-1 human monocytic leukemic cell line, with an IC50 of 4.0±0.08 μM[1].


[References]

[1]. Zelová H, et al. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. J Nat Prod. 2014 Jun 27;77(6):1297-303.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
678.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H28O6

[ Molecular Weight ]:
424.486

[ Flash Point ]:
232.0±25.0 °C

[ Exact Mass ]:
424.188599

[ PSA ]:
107.22000

[ LogP ]:
6.60

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.629

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds