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Lagosin

Names

[ CAS No. ]:
6834-98-6

[ Name ]:
Lagosin

[Synonym ]:
Pentamycin
S 232
all-trans-3,5,7,9,11,13,14,15,26,27-Decahydroxy-2,1'-hydroxyhexyl-16-methyl-octacosa-16,18,20,22,24-pentaen-saeure-1->27-lacton
14-Hydroxyfilipin
Cogomycin
Antibiotic A-246
Lagosin (antibiotic)
EINECS 229-913-4
Lagosin
Fungichromin

Biological Activity

[Description]:

Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to drug resistance[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Lagosin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum[1].

[References]

[1]. Peng C, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020;104(24):10437-10449.

Chemical & Physical Properties

[ Density]:
1.196g/cm3

[ Boiling Point ]:
914ºC at 760 mmHg

[ Molecular Formula ]:
C35H58O12

[ Molecular Weight ]:
670.83

[ Flash Point ]:
278.4ºC

[ Exact Mass ]:
670.39300

[ PSA ]:
228.60000

[ LogP ]:
0.85880

[ Index of Refraction ]:
1.545

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LT3850000
CHEMICAL NAME :
Fungichromin
CAS REGISTRY NUMBER :
6834-98-6
LAST UPDATED :
199512
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C35-H58-O12
MOLECULAR WEIGHT :
670.93
WISWESSER LINE NOTATION :
T-28-OV RU TU VU A&U C&UTJ CYQ5 DQ FQ HQ JQ LQ NQ OQ PQ R1 E&Q F&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1624 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,26,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,716,1954/1955

Related Compounds

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