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20-(Tert-Butoxy)-20-Oxoicosanoic Acid

Names

[ CAS No. ]:
683239-16-9

[ Name ]:
20-(Tert-Butoxy)-20-Oxoicosanoic Acid

[Synonym ]:
Eicosanedioic acid, mono(1,1-dimethylethyl) ester
20-[(2-Methyl-2-propanyl)oxy]-20-oxoicosanoic acid

Biological Activity

[Description]:

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
496.0±18.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H46O4

[ Molecular Weight ]:
398.620

[ Flash Point ]:
152.4±14.7 °C

[ Exact Mass ]:
398.339600

[ PSA ]:
63.60000

[ LogP ]:
8.87

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.463

[ Water Solubility ]:
Insuluble (2.0E-4 g/L) (25 ºC)

Related Compounds