TMOS

Names

[ CAS No. ]:
681-84-5

[ Name ]:
TMOS

[Synonym ]:
Silane, tetra(methoxy)-
tetramethoxy-silan
Tetra-methyl orthosilicate
tl190
methyl orthosilicate
SILICATE,METHYL
silicon tetramethoxide
Tetramethosysilan
Dynasil M
tetramethoxylsilane
O-METHYLSILICATE
EINECS 211-656-4
Silicic acid (HSiO), tetramethyl ester
Tetramethyl silicate
tetramethoxy-silane
METHYLSILICATE
Tetramethyl orthosilicate
TMOS
MFCD00008341
tetramethoxysilane
tetramethyloxysilane
orthosilicic acid tetramethyl ester

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
121.2±8.0 °C at 760 mmHg

[ Melting Point ]:
−4 °C(lit.)

[ Molecular Formula ]:
C₄H₁₂O₄Si

[ Molecular Weight ]:
152.221

[ Flash Point ]:
28.9±0.0 °C

[ Exact Mass ]:
152.050491

[ PSA ]:
36.92000

[ LogP ]:
2.97

[ Vapour density ]:
5.25 (vs air)

[ Vapour Pressure ]:
17.7±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.382

[ Water Solubility ]:
hydrolysis

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VV9800000

CHEMICAL NAME :: Silicic acid, tetramethyl ester

CAS REGISTRY NUMBER :: 681-84-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C4-H12-O4-Si

MOLECULAR WEIGHT :: 152.25

WISWESSER LINE NOTATION :: 1O-SI-O1&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: 30ZNA5 "Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980 Volume(issue)/page/year: 3,935,1968

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1222,1986

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/m3/10M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Musculoskeletal - other changes

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,MAY1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 2,56,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 17 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: 30ZNA5 "Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980 Volume(issue)/page/year: 3,935,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** REVIEWS *** ACGIH TLV-TWA 6 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 5 ppm (30 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,169,1971 OSHA PEL (Construc):8H TWA 5 ppm (30 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (30 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-DENMARK:STEL 1 ppm (6 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (30 mg/m3);STEL 10 ppm (60 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 5 ppm (30 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL SILICATE-air:10H TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H315-H318-H330

[ Precautionary Statements ]:
P210-P260-P280-P304 + P340 + P310-P305 + P351 + P338 + P310-P370 + P378

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R10;R26;R37/38;R41

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2606 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
VV9800000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

[ HS Code ]:
29209085

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2920909090

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Related Compounds

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