2-AMINO-3-METHYL-9H-PYRIDO[2,3-B]INDOLE
Names
Chemical & Physical Properties
[ Density]:
1.334g/cm3
[ Boiling Point ]:
443.2ºC at 760mmHg
[ Melting Point ]:
215-218ºC
[ Molecular Formula ]:
C12H11N3
[ Molecular Weight ]:
197.23600
[ Flash Point ]:
252.1ºC
[ Exact Mass ]:
197.09500
[ PSA ]:
54.70000
[ LogP ]:
3.18790
[ Index of Refraction ]:
1.806
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU9354380
- CHEMICAL NAME :
- 9H-Pyrido(2,3-b)indole, 2-amino-3-methyl-
- CAS REGISTRY NUMBER :
- 68006-83-7
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C12-H11-N3
- MOLECULAR WEIGHT :
- 197.26
- WISWESSER LINE NOTATION :
- T B656 FN HMJ D1 EZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32800 mg/kg/85W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37380 mg/kg/64W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35424 mg/kg/70W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- DNA adduct
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 125 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 269,79,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,253,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,253,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
UN 2811
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%