Vitamin B12
Names
[ CAS No. ]:
68-19-9
[ Name ]:
Vitamin B12
[Synonym ]:
cob(II)alamin
vitral
Vb12
cotel
vibalt
embiol
Vitamin b12
Cyanocobalamin
CN-13-epiCbl
covit
cn-b12
vitamin B-12
cyomin
EINECS 200-680-0
MFCD00151092
Bedoz
CN-CBL
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Melting Point ]:
>300ºC
[ Molecular Formula ]:
C63H88CoN14O14P
[ Molecular Weight ]:
1355.365
[ Exact Mass ]:
1354.567383
[ PSA ]:
479.70000
[ LogP ]:
6.57018
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GG3750000
- CHEMICAL NAME :
- Cobinamide, cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole, inner salt
- CAS REGISTRY NUMBER :
- 68-19-9
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C63-H88-Co-N14-O14-P
- MOLECULAR WEIGHT :
- 1355.55
- WISWESSER LINE NOTATION :
- D C5656 B-5 B6 B5 S5 J&5 B-19- Q&6 N&5/B-N/DU/J&-M& J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1364 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2727 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - other changes
- REFERENCE :
- ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 115 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 242,263,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 168 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 84 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80358 No. of Facilities: 1219 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 19601 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80358 No. of Facilities: 3495 (estimated) No. of Industries: 12 No. of Occupations: 46 No. of Employees: 65178 (estimated) No. of Female Employees: 27980 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
11-23/24/25-39/23/24/25
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution
[ WGK Germany ]:
1
[ RTECS ]:
GG3750000
[ HS Code ]:
2936260000
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2936260000
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