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Sembragiline

Names

[ CAS No. ]:
676479-06-4

[ Name ]:
Sembragiline

[Synonym ]:
K3W9672PNJ
UNII-K3W9672PNJ
Acetamide, N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-3-pyrrolidinyl]-
RG1577
Sembragiline
N-[(3S)-1-{4-[(3-Fluorobenzyl)oxy]phenyl}-5-oxo-3-pyrrolidinyl]acetamide
MFCD28963964

Biological Activity

[Description]:

Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A; displays no affinity for more than 100 different receptors, enzymes and ion channels; protects against neuronal loss and reduces both ROS formation and reactive astrogliosis in transgenic animal model conditionally overexpressing MAO-B in astroglia, exhibits potential for treatment of Alzheimer's disease (AD) and other neurodegenerative disorders. Alzheimer Disease Phase 2 Clinical

[References]

References 1. Borroni E, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):413-423. 2. Nave S, et al. J Alzheimers Dis. 2017;58(4):1217-1228. 3. Yeon SK, et al. Bioorg Med Chem. 2018 Jan 1;26(1):232-244. View Related Products by Target Monoamine Oxidase (MAO) Alzheimer Disease

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
644.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19FN2O3

[ Molecular Weight ]:
342.364

[ Flash Point ]:
343.5±31.5 °C

[ Exact Mass ]:
342.137970

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds