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Spathulenol

Names

[ CAS No. ]:
6750-60-3

[ Name ]:
Spathulenol

[Synonym ]:
spathulenol
(1aR,4aR,7S,7aR,7bR)-1,1,7-Trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulen-7-ol
1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, (1aR,4aR,7S,7aR,7bR)-
Espatulenol
10'-Apocarotenal

Biological Activity

[Description]:

Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Spathulenol exhibits a high antioxidant activity s in the DPPH and MDA system, exhibits significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].

[In Vivo]

Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model[1]. In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature andoxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which iscomparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA,which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations[1].

[References]

[1]. Nascimento KF, et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.J Ethnopharmacol. 2018 Jan 10;210:351-358.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
297.0±19.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H24O

[ Molecular Weight ]:
220.350

[ Flash Point ]:
123.9±13.7 °C

[ Exact Mass ]:
220.182709

[ PSA ]:
20.23000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.528

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds