PEG3

Names

[ Name ]:
PEG3

[Synonym ]:
2-[3-(2-hydroxyethoxy)propoxy]ethan-1-ol
1,3-Bis-(2-hydroxy-aethoxy)-propan
2,2'-propane-1,3-diyldioxy-bis-ethanol
2,2'-(Trimethylenedioxy)diethanol
Ethanol,2,2'-[1,3-propanediylbis(oxy)]bis
3,7-Dioxa-1,9-nonanediol
1,9-Dihydroxy-3,7-dioxanonane
3,7-dioxa-nonane-1,9-diol
1,3-bis-(2-hydroxy-ethoxy)-propane

Biological Activity

[Description]:

PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.091 g/mL at 20ºC

[ Boiling Point ]:
283.02ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₁₆O₄

[ Molecular Weight ]:
164.20000

[ Flash Point ]:
124.966ºC

[ Exact Mass ]:
164.10500

[ PSA ]:
58.92000

[ Index of Refraction ]:
n20/D 1.456

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
C

[ RIDADR ]:
NONH for all modes of transport