moronic acid

Names

[ Name ]:
moronic acid

[Synonym ]:
Olean-18-en-28-oic acid, 3-oxo-
(4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid
3-Oxoolean-18-en-28-oic acid
moronic acid
Moronsaeure

Biological Activity

[Description]:

Moronic acid, a triterpenoid, is an anti-HIV agent. Moronic acid inhibits viral replication with an EC50 value <1 μg/mL, and shows cytotoxicity in H9 lymphocytes with an IC50 value of 18.6 μg/mL. Moronic acid can be isolated from Brazilian propolis[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[References]

[1]. Ito J, et al. Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod. 2001 Oct;64(10):1278-81.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
550.0±50.0 °C at 760 mmHg

[ Melting Point ]:
212 °C(dec.)

[ Molecular Formula ]:
C₃₀H₄₆O₃

[ Molecular Weight ]:
454.68

[ Flash Point ]:
300.5±26.6 °C

[ Exact Mass ]:
454.344696

[ PSA ]:
54.37000

[ LogP ]:
8.53

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.552

Synthetic Route

Click to get detail synthetic route

Related Compounds

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