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Esculin sesquihydrate

Names

[ CAS No. ]:
66778-17-4

[ Name ]:
Esculin sesquihydrate

[Synonym ]:
7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1)
MFCD00149492
2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1)
EINECS 208-517-5
7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one,hydrate

Biological Activity

[Description]:

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[References]

[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807.  

[2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.  

Chemical & Physical Properties

[ Density]:
0.791 g/mL at 20 °C

[ Melting Point ]:
203-205 °C

[ Molecular Formula ]:
C15H16O9.3/2H2O

[ Molecular Weight ]:
367.31

[ Exact Mass ]:
358.089996

[ PSA ]:
159.05000

Safety Information

[ Hazard Codes ]:
F;C

[ Risk Phrases ]:
11-20/21/22-34-68/20/21/22-36/37/38

[ Safety Phrases ]:
26-36/37/39-45-36/37

[ RIDADR ]:
UN 2924 3/PG 2

[ WGK Germany ]:
3.0

Related Compounds