N-trans-Feruloyltyramine

Names

[ Name ]:
N-trans-Feruloyltyramine

[Synonym ]:
6,7-dimethoxy-5-hydroxyflavone
5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
N-trans-Feruloyltyramine
(1E,2E)-3-(4-Hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-propenimidic acid
5-Hydroxy-6,7-dimethoxyflavone
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide
5-hydroxy-6,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one
6,7-di-O-methyl-baicalein
moupinamide
2-Propenimidic acid, 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-, (1E,2E)-
4H-1-Benzopyran-4-one,5-hydroxy-6,7-dimethoxy-2-phenyl
baicalein 6,7-dimethyl ether
2-Propenamide, 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-, (2E)-
Mosloflavone

Biological Activity

[Description]:

N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1

COX-2

[References]

[1]. Aswad M, et al. Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity. Inflamm Res. 2018 Jan;67(1):67-75.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
554.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉NO₄

[ Molecular Weight ]:
313.348

[ Flash Point ]:
289.0±32.9 °C

[ Exact Mass ]:
313.131409

[ PSA ]:
78.79000

[ LogP ]:
3.33

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.566

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50

[ Safety Phrases ]:
61

[ RIDADR ]:
UN 3077 9 / PGIII

Precursor & DownStream

Precursor

DownStream

Articles

Transgenic tomato plants overexpressing tyramine N-hydroxycinnamoyltransferase exhibit elevated hydroxycinnamic acid amide levels and enhanced resistance to Pseudomonas syringae.

Mol. Plant Microbe Interact. 27(10) , 1159-69, (2014)

Hydroxycinnamic acid amides (HCAA) are secondary metabolites involved in plant development and defense that have been widely reported throughout the plant kingdom. These phenolics show antioxidant, an...

A feruloyltyramine trimer isolated from potato common scab lesions

Phytochemistry 71(17-18) , 2187-9, (2010)

Graphical abstract A lignanamide isolated from potato common scab lesions was characterized as a feruloyltyramine trimer by MS and NMR techniques.

Endosperm-specific expression of serotonin N-hydroxycinnamoyltransferase in rice.

Plant Foods Hum. Nutr. 63(2) , 53-7, (2008)

Serotonin N-hydroxycinnamoyltransferase (SHT) is a key enzyme in the synthesis of feruloylserotonin (FS) and 4-coumaroylserotonin (CS). These serotonin derivatives show strong antioxidant activity, ma...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.