methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate,hydrochloride
Names
[ CAS No. ]:
66634-44-4
[ Name ]:
methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate,hydrochloride
[Synonym ]:
Prestwick_751
Rauhimbine
17|A-Hydroxyyohimban-16|A-carboxylic acid methyl ester
EINECS 266-430-8
17alpha-Hydroxyyohimban-16beta-carboxylic acid methyl ester
MFCD00064554
Chlorhydrate de corynanthine
Chemical & Physical Properties
[ Molecular Formula ]:
C21H27ClN2O3
[ Molecular Weight ]:
390.90400
[ Exact Mass ]:
390.17100
[ PSA ]:
65.56000
[ LogP ]:
3.38700
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ZG1025000
- CHEMICAL NAME :
- Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 66634-44-4
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H26-N2-O3.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,241,1935
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 158 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 146,1042,1952