NH2-PEG4-CH2CH2COOH

Names

[ Name ]:
NH2-PEG4-CH2CH2COOH

[Synonym ]:
AmbotzPEG1370
Amino-PEG4-acid
15-amino-4,7,10,13-tetraoxapentadecanoic acid
1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-amino-
H2N-PEG4-COOH

Biological Activity

[Description]:

NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) having enzymatically cleavable groups. WO2018114578A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
409.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₃NO₆

[ Molecular Weight ]:
265.303

[ Flash Point ]:
201.5±27.3 °C

[ Exact Mass ]:
265.152527

[ PSA ]:
100.24000

[ LogP ]:
-1.92

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.469

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%