Alendronic acid

Names

[ Name ]:
Alendronic acid

[Synonym ]:
(4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid

Biological Activity

[Description]:

Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2].

[References]

[1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293.

[2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032.

Chemical & Physical Properties

[ Density]:
1.857 g/cm3

[ Boiling Point ]:
616.7ºC at 760 mmHg

[ Melting Point ]:
230-235ºC

[ Molecular Formula ]:
C₄H₁₃NO₇P₂

[ Molecular Weight ]:
249.09600

[ Flash Point ]:
326.7ºC

[ Exact Mass ]:
249.01700

[ PSA ]:
180.93000

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
1759

[ RTECS ]:
SZ6521833

[ Packaging Group ]:
III

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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