BL-140
Names
[ CAS No. ]:
663620-66-4
[ Name ]:
BL-140
Biological Activity
[Description]:
A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.
[References]
References 1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198. View Related Products by Target PI3K
Chemical & Physical Properties
[ Molecular Formula ]:
C18H21N5O2S
[ Molecular Weight ]:
371.459
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.