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Dihydroguaiaretic acid

Names

[ CAS No. ]:
66322-34-7

[ Name ]:
Dihydroguaiaretic acid

[Synonym ]:
Tetrahydrothebaine
Dihydroguaiaretic acid
4,4'-dihydroxy-3,3'-dimethoxylignan
4,5alpha-Epoxy-3,6-dimethoxy-17-methylmorphinan
4-[(2R,3S)-4-(4-Hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
Phenol, 4-[(2R,3S)-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-
meso-4,4'-dihydroxy-3,3'-dimethoxylignane
meso-dihydroguaiaretic acid

Biological Activity

[Description]:

Dihydroguaiaretic acid, is isolated from the fruits of Schisandra chinensis with an anti-cancer activty[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Dihydroguaiaretic acid shows inhibitory effect on Human ovarian cancer cells and A2780 Human endometrial cancer cells Ishikawa with IC50 values of 27.17 μM and 45.46 μM, respectively[1].

[References]

[1]. Arch Pharm Res. 2017 Apr;40(4):500-508. doi: 10.1007/s12272-017-0902-5. Epub 2017 Feb 22.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
488.3±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H26O4

[ Molecular Weight ]:
330.418

[ Flash Point ]:
249.1±27.3 °C

[ Exact Mass ]:
330.183105

[ PSA ]:
58.92000

[ LogP ]:
4.33

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.564

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds