Sulfinalol

Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity[1].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

β-adrenoceptor

Sulfinalol shows direct vasodilator activity and antihypertensive activity[1]. Animal Model: Mongrel dogs weighing 8.7-21.2 kg were anesthetized with pentobarbital (30-35 mg/kg, i.v., followed by a continuous infusion of 4 mg/kg/h)[1] Dosage: 0-100 µg Administration: Intraarterial injection Result: Increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 2.5 mg/kg Administration: Oral administration Result: Reduced pressure of conscious spontaneously hypertensive rats.

[1]. E J Sybertz, et al. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58.