SirT1 enhancer A03

Names

[ Name ]:
SirT1 enhancer A03

[Synonym ]:
L-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester
(S)-alaproclate
DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester
1-(4-chlorophenyl)-2-methylpropan-2-yl L-alaninate
1-(4-Chlorophenyl)-2-methyl-2-propanyl L-alaninate

Biological Activity

[Description]:

SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity

[References]

References 1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574. View Related Products by Target Sirtuin

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
335.1±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₈ClNO₂

[ Molecular Weight ]:
255.740

[ Flash Point ]:
156.5±22.3 °C

[ Exact Mass ]:
255.102600

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.528

Related Compounds

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