4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Names

[ Name ]:
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

[Synonym ]:
BW-755C
1-(m-trifluoromethylphenyl)-3-amino-2-pyrazoline
1-[3-(trifluoromethyl)phenyl]-3-amino-2-pyrazoline
3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
1-(3-trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine
1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine
4,5-dihydro-1-(3-(trifluoromethyl)-phenyl)-1H-pyrazol-3-amine
T0504-7356
1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-
1H-Pyrazol-3-amine, 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-
3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline

Biological Activity

[Description]:

BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

5-LO:5 μM (IC50)

COX-1:0.65 μg/mL (IC50)

COX-2:1.2 μg/mL (IC50)

[In Vivo]

BW 755C (0.03-10 mg/rat; s.c.; once) 抑制大鼠排卵率及卵巢 5-HETE 和 12-HETE 水平[3]。 Animal Model: Immature Wistar rats ~22 days of age[3] Dosage: 0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat Administration: Subcutaneous injection, once Result: Reduced 5-HETE (moderately) and 12-HETE (strongly).

[References]

[1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70.

[2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.

[3]. Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
308.5±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₀F₃N₃

[ Molecular Weight ]:
229.20

[ Flash Point ]:
140.4±30.7 °C

[ Exact Mass ]:
229.082687

[ PSA ]:
39.12000

[ LogP ]:
1.94

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.559

Safety Information

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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