SK 216

Names

[ Name ]:
SK 216

[Synonym ]:
Propanedioic acid, 2-[5-[[6-[5-(1,1-dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-, sodium salt (1:2)
Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate

Biological Activity

[Description]:

SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM; reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model, also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.

[References]

References 1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88. 2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9. 3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉NO₆Na₂

[ Molecular Weight ]:
533.523

[ Exact Mass ]:
533.179016

Related Compounds

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