1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Names
[ CAS No. ]:
65154-06-5
[ Name ]:
1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE
[Synonym ]:
AGEPC
Blood platelet activating factor-acether
1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
Antihypertensive polar renomedullary lipid
Platelet activating factor phosphatidate
Chemical & Physical Properties
[ Molecular Formula ]:
C26H54NO7P
[ Molecular Weight ]:
523.68300
[ Exact Mass ]:
523.36400
[ PSA ]:
103.93000
[ LogP ]:
6.69400
[ Storage condition ]:
20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EC6060000
- CHEMICAL NAME :
- Blood platelet-activating factor
- CAS REGISTRY NUMBER :
- 65154-06-5
- LAST UPDATED :
- 199609
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14800 ng/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 40,227P,1986
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-38-40-48/20/22
[ Safety Phrases ]:
36/37-24/25-22
[ RIDADR ]:
UN 1888 6.1/PG 3
[ RTECS ]:
EC6060000
Articles
Cell Calcium 5(5) , 463-73, (1984)
Platelet-activating factor (1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF) is a potent inducer of shape-change, aggregation and secretion in platelets. PAF causes a rapid increase in intrace...