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Ethacrynic acid sodium

Names

[ CAS No. ]:
6500-81-8

[ Name ]:
Ethacrynic acid sodium

[Synonym ]:
UNII-K41MYV7MPM
Edecrin Sodium
Acetic acid,(2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)-,sodium salt
ETHACRYNATE SODIUM
Ethacrynate sodium (USP)
Sodium ethacrynate
Ethacrynic acid sodium
Sodium edecrin

Biological Activity

[Description]:

Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase
Research Areas >> Inflammation/Immunology

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  

Chemical & Physical Properties

[ Boiling Point ]:
480ºC at 760 mmHg

[ Melting Point ]:
121-122ºC

[ Molecular Formula ]:
C13H11Cl2NaO4

[ Molecular Weight ]:
325.12

[ Flash Point ]:
244.1ºC

[ Exact Mass ]:
323.99300

[ PSA ]:
66.43000

[ LogP ]:
2.27100

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds