N-(4-Carboxycyclohexylmethyl)maleimide

Names

[ Name ]:
N-(4-Carboxycyclohexylmethyl)maleimide

[Synonym ]:
Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid

Biological Activity

[Description]:

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
433.6±18.0 °C at 760 mmHg

[ Melting Point ]:
157-158ºC

[ Molecular Formula ]:
C₁₂H₁₅NO₄

[ Molecular Weight ]:
237.252

[ Flash Point ]:
216.0±21.2 °C

[ Exact Mass ]:
237.100113

[ PSA ]:
74.68000

[ LogP ]:
1.13

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

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