glucosylmannitol

Names

[ Name ]:
glucosylmannitol

[Synonym ]:
1-O-α-D-Glucopyranosyl-D-mannitol
Plaltinitol
PALATINOL
ISOMALT USP
MFCD00190708
PALATINIT
hydrogenated isomaltulose
glucosylmannitol
Isomaltitol
EINECS 203-252-1
D-mannitol, 1-O-a-D-glucopyranosyl-
1-O-a-D-glucopyranosyl-D-mannitol
D-Mannitol, 1-O-α-D-glucopyranosyl-
PALATINITOL

Biological Activity

[Description]:

Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

Research Areas >> Metabolic Disease

[In Vivo]

The chronic toxicity of orally administered isomalt as a part of diet has been studied in animals and it was found to be a safe substance. It did not affect the mortality rate of the animals, and there was no evidence of carcinogenicity, or adverse effects on fertility, reproductive performance or development[1].

[References]

[1]. Tuderman AK, et al. Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase. Int J Pharm. 2018 Mar 1;538(1-2):287-295.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
788.5±60.0 °C at 760 mmHg

[ Melting Point ]:
215-217°C

[ Molecular Formula ]:
C₁₂H₂₄O₁₁

[ Molecular Weight ]:
344.312

[ Flash Point ]:
430.7±32.9 °C

[ Exact Mass ]:
344.131866

[ PSA ]:
401.06000

[ LogP ]:
-5.72

[ Vapour Pressure ]:
0.0±6.2 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4394500

CHEMICAL NAME :: D-Glucitol, 6-O-alpha-D-glucopyranosyl-, mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol

CAS REGISTRY NUMBER :: 64519-82-0

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H24-O11.C12-H24-O11

MOLECULAR WEIGHT :: 688.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 125 mg/kg

SEX/DURATION :: female 5 day(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 27,631,1989

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
22-26-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
LZ4394500

[ HS Code ]:
2940000000

Customs

[ HS Code ]: 2940000000

Articles

Assessment of isomalt for colon-specific delivery and its comparison with lactulose.

AAPS PharmSciTech 14(1) , 53-9, (2013)

Lactulose is used as a triggering substance in a unique colon-specific delivery technology called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODES...

Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers.

Br. J. Nutr. 95(1) , 40-50, (2006)

Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week pe...

Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers.

Br. J. Nutr. 94(4) , 575-81, (2005)

The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined ...

Related Compounds

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