3-NITROBENZAMIDE
Names
[ CAS No. ]:
645-09-0
[ Name ]:
3-NITROBENZAMIDE
[Synonym ]:
MFCD00007984
EINECS 211-431-0
3-nitrobenzamide
Chemical & Physical Properties
[ Density]:
1.431g/cm3
[ Boiling Point ]:
310 - 315ºC
[ Melting Point ]:
140-143 °C(lit.)
[ Molecular Formula ]:
C7H6N2O3
[ Molecular Weight ]:
166.13400
[ Flash Point ]:
145.852ºC
[ Exact Mass ]:
166.03800
[ PSA ]:
88.91000
[ LogP ]:
1.91720
[ Index of Refraction ]:
1.618
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CV5601250
- CHEMICAL NAME :
- Benzamide, 3-nitro-
- CAS REGISTRY NUMBER :
- 645-09-0
- BEILSTEIN REFERENCE NO. :
- 0777185
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H6-N2-O3
- MOLECULAR WEIGHT :
- 166.15
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 28,335,1994
Safety Information
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
CV5601250
[ HS Code ]:
2924299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Biochem. J. 185 , 775-777, (1980)
In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. T...
Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.J. Biol. Chem. 257(11) , 6084-8, (1982)
We have shown previously that alloxan and streptozotocin, two major diabetogenic agents, cause DNA strand breaks in rat pancreatic islets and stimulate nuclear poly(ADP-ribose) synthetase, thereby dep...