Homo Sildenafil

Names

[ Name ]:
Homo Sildenafil

[Synonym ]:
5-[2-ETHOXY-5-[(4-ETHYL-(PIPERAZIN-1-YL))SULFONYL]PHENYL]-1,6-DIHYDRO-1-METHYL-3-PROPYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE
5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
PYR397
5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
Homo Sildenafil
5-{2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
UNII-0Z3JH0S0QK

Biological Activity

[Description]:

Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[References]

[1]. Jackie D Corbin, et al. Vardenafil: Structural Basis for Higher Potency Over Sildenafil in Inhibiting cGMP-specific phosphodiesterase-5 (PDE5). Neurochem Int. 2004 Nov;45(6):859-63.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
200-202ºC

[ Molecular Formula ]:
C₂₃H₃₂N₆O₄S

[ Molecular Weight ]:
488.603

[ Exact Mass ]:
488.220581

[ PSA ]:
121.80000

[ LogP ]:
2.80

[ Index of Refraction ]:
1.656

[ Storage condition ]:
-20 °C

Synthetic Route

Click to get detail synthetic route

Related Compounds

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