BRD 6989

Names

[ CAS No. ]:
642008-81-9

[ Name ]:
BRD 6989

[Synonym ]:
3-Quinolinecarbonitrile, 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-
2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydro-3-quinolinecarbonitrile
MFCD04013193

Biological Activity

[Description]:

A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM); inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.

[References]

References 1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108. View Related Products by Target Cyclin-dependent Kinase (CDK)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
496.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₆N₄

[ Molecular Weight ]:
264.325

[ Flash Point ]:
254.2±28.7 °C

[ Exact Mass ]:
264.137512

[ LogP ]:
3.69

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.