3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

Names

[ Name ]:
3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride

[Synonym ]:
DESME
propildazine
Propyldazine
TRUST
radar
FORDO
orbit
Dadar
TILT
JUNO
desmel

Biological Activity

[Description]:

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1]. Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2]. Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3]. Animal Model: Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1] Dosage: 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively Administration: Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age Result: Resulted over 80% of mice alive beyond 78 weeks of age.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₅N₅O

[ Molecular Weight ]:
197.23800

[ Exact Mass ]:
197.12800

[ PSA ]:
90.53000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR6550000

CHEMICAL NAME :: 3(2H)-Pyridazinone, 6-((2-hydroxypropyl)methylamino)-, hydrazone

CAS REGISTRY NUMBER :: 64000-73-3

BEILSTEIN REFERENCE NO. :: 0649354

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H15-N5-O

MOLECULAR WEIGHT :: 197.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 1 mg/plate

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 5,339,1985

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%