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hygromycin A

Names

[ CAS No. ]:
6379-56-2

[ Name ]:
hygromycin A

[Synonym ]:
Homomycin
Totomycin
Homomycin (6CI)
Hygromycin A

Biological Activity

[Description]:

Hygromycin A is a Borrelia burgdorferi-selective antibiotic. Hygromycin A is a spirochete-specific antibacterial that is conducive to gut health. Hygromycin A can be used for Lyme disease research[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Arnaboldi PM, et al. Hygromycin A in the Lymelight. Cell Host Microbe. 2021 Nov 10;29(11):1599-1601.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H29NO12

[ Molecular Weight ]:
511.48

[ Exact Mass ]:
511.16900

[ PSA ]:
207.96000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NG8859000
CHEMICAL NAME :
D-nes-Inositol, 5-deoxy-5-((3-(4-((6-deoxy-beta-D-arabino-hexofuranos -5-ulos-1-yl)oxy)-3- hydroxyphenyl)-2-methyl-1-oxo-2-propenyl)amino)-1,2-O -methylene-, (E)-
CAS REGISTRY NUMBER :
6379-56-2
LAST UPDATED :
198909
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H29-N-O12
MOLECULAR WEIGHT :
511.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1067 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,656,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,332,1981

Related Compounds

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