<Suppliers Price>

NH-bis-PEG5

Names

[ CAS No. ]:
63721-06-2

[ Name ]:
NH-bis-PEG5

[Synonym ]:
3,6,9,12,18,21,24,27-Octaoxa-15-azanonacosane-1,29-diol

Biological Activity

[Description]:

NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C20H43NO10

[ Molecular Weight ]:
457.55600

[ Exact Mass ]:
457.28900

[ PSA ]:
126.33000


Related Compounds