Nuarimol
Names
[ CAS No. ]:
63284-71-9
[ Name ]:
Nuarimol
[Synonym ]:
Gauntlet
UNII:ZU7K80U0CY
murox
Caswell No. 419G
trimifruitsc
triminol
el2289
Trimiol
Nuarimol
α-(2-Chlorophenyl)-α-(4-fluorophenyl)-5-pyrimidinemethanol
(2-chlorophenyl)(4-fluorophenyl)pyrimidin-5-ylmethanol
el228
(2-Chlorphenyl)(4-fluorphenyl)pyrimidin-5-ylmethanol
(RS)-2-chloro-4’-fluoro-α-(pyrimidin-5-yl)benzhydryl alcohol
(2-Chlorophenyl)(4-fluorophenyl)5-pyrimidinylmethanol
a-(2-Chlorophenyl)-a-(4-fluorophenyl)-5-pyrimidinemethanol
MFCD00078677
(RS)-2-Chloro-4'-fluoro-a-(pyrimidin-5-yl)benzhydryl alcohol
rac-(R)-(2-chlorophenyl)(4-fluorophenyl)(pyrimidin-5-yl)methanol
(±)-Nuarimol
TRIMIDAL
guantlet
EINECS 264-071-1
5-Pyrimidinemethanol, α-(2-chlorophenyl)-α-(4-fluorophenyl)-
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
475.2±40.0 °C at 760 mmHg
[ Melting Point ]:
126°C
[ Molecular Formula ]:
C17H12ClFN2O
[ Molecular Weight ]:
314.741
[ Flash Point ]:
241.2±27.3 °C
[ Exact Mass ]:
314.062225
[ PSA ]:
46.01000
[ LogP ]:
2.68
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.623
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV9279700
- CHEMICAL NAME :
- 5-Pyrimidinemethanol, alpha-(2-chlorophenyl)-alpha-(4-fluorophenyl)-
- CAS REGISTRY NUMBER :
- 63284-71-9
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C17-H12-Cl-F-N2-O
- MOLECULAR WEIGHT :
- 314.76
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A303,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 312 mg/kg/5D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,337,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8736 mg/kg/2Y-C
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545244
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-36
[ Safety Phrases ]:
S26
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UV9279700
Precursor & DownStream
Precursor
DownStream
Articles
Anal. Bioanal. Chem 404(6-7) , 1983-91, (2012)
A method for simultaneous enantioselective determination of fenarimol and nuarimol in apple, grape, cucumber, tomato, and soil was developed using liquid chromatography-tandem mass spectrometry. The e...
Pesticide analysis in tomatoes by solid-phase microextraction and micellar electrokinetic chromatography.J. Chromatogr. A. 1185(1) , 151-4, (2008)
The analysis of a group of seven pesticides (i.e. six fungicides: pyrimethanil, procymidone, nuarimol, fenarimol, benalaxyl and penconazole and one insecticide: pirimicarb) in tomato samples by micell...
[The effect of nuarimol on the mutagenic activity of n-nitrosodimethylamine and 2-acetylaminofluorene in mouse erythrocytes].Rocz. Panstw. Zakl. Hig. 49(1) , 55-66, (1998)
Nuarimol, the structural analogue of DDT, similarly to other polychlorinated aromatic hydrocarbons, induces monoxygenase activity. N-nitrosodimethylamine (NDMA) and 2-acetylaminofluorene (2-AAF) belon...