N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

Names

[ Name ]:
N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

[Synonym ]:
4,4'-Sulfandiyl-di-buttersaeure-bis-salicylidenhydrazid
4,4'-sulfanediyl-di-butyric acid bis-salicylidenehydrazide

Biological Activity

[Description]:

Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> NF-κB >> Keap1-Nrf2

[References]

[1]. Aboulkassim T, et al. A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Cell Rep. 2023 Sep 12;42(9):113104.

Chemical & Physical Properties

[ Density]:
1.351g/cm3

[ Boiling Point ]:
621.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₆N₄O₄S

[ Molecular Weight ]:
442.53

[ Flash Point ]:
329.9ºC

[ Exact Mass ]:
442.16700

[ PSA ]:
148.68000

[ LogP ]:
3.77360

[ Index of Refraction ]:
1.681

Related Compounds

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