(±)-threo-3-Methylglutamic acid

Names

[ Name ]:
(±)-threo-3-Methylglutamic acid

[Synonym ]:
(±)-threo-3-Methylglutamic acid

Biological Activity

[Description]:

(±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2

Research Areas >> Metabolic Disease

[In Vitro]

(±)-threo-3-Methylglutamic acid (0-300 µM) 以浓度依赖性方式抑制视杆外节对谷氨酸的摄取，IC50 值为 38.35 µM[2]。

[References]

[1]. Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7.

[2]. Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51.

Chemical & Physical Properties

[ Density]:
1.329g/cm3

[ Boiling Point ]:
329.4ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₁NO₄

[ Molecular Weight ]:
161.15600

[ Flash Point ]:
153ºC

[ Exact Mass ]:
161.06900

[ PSA ]:
100.62000

[ LogP ]:
0.20940

[ Appearance of Characters ]:
white to off-white

[ Index of Refraction ]:
1.512

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
H2O: >1.5mg/dL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Guide to Receptors and Channels (GRAC), 4th Edition.

Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009)

In vitro comparison of the effect of inhalation delay and flow rate on the emitted dose from three valved holding chambers.

J. Aerosol Med. Pulm. Drug Deliv. 27 Suppl 1 , S37-43, (2014)

Valved holding chambers (VHCs) are accessory devices for pressurized metered dose inhalers (pMDIs). Use of a VHC may help overcome coordination issues associated with drug delivery via the pMDI alone....

Related Compounds

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