m-PEG4-Tos

Names

[ Name ]:
m-PEG4-Tos

[Synonym ]:
2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethyl 4-methylbenzenesulfonate
toluene-4-sulfonic acid 2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethyl ester
2,5,8,11-Tetraoxatridecan-13-ol,4-methylbenzenesulfonate
CH3(OCH2CH2)4OTs
CH3[O(CH2)2]4OTs
(2,5,8,11-tetraoxatridecan-13-yl) p-toluenesulfonate
2,5,8,11-tetraoxatridecan-13-ol tosylate

Biological Activity

[Description]:

m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₆O₇S

[ Molecular Weight ]:
380.45400

[ Exact Mass ]:
380.15000

[ PSA ]:
119.90000

[ LogP ]:
1.99740

Synthetic Route

Click to get detail synthetic route

Related Compounds

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