4-Chlorobenzonitrile
Names
[ CAS No. ]:
623-03-0
[ Name ]:
4-Chlorobenzonitrile
[Synonym ]:
p-chlorobenzonitrile
4-chloro-benzonitrile
para-chloro-benzonitrile
MFCD00001813
EINECS 210-765-4
4-chloro-benzonitril
p-Chlorbenzonitril
P-CHLORBENZONITRILE
4-Chlorbenzolcarbonitril
Benzonitrile, 4-chloro-
para-cyano chlorobenzene
p-Chlorotolunitrile
4-Chlorobenzonitrile
1-chloro-4-cyanobenzene
PCBN
p-chloro-benzonitril
p-chlorobenzylnitrile
4-CYANOCHLOROBENZENE
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
223.0±0.0 °C at 760 mmHg
[ Melting Point ]:
90-93 °C(lit.)
[ Molecular Formula ]:
C7H4ClN
[ Molecular Weight ]:
137.566
[ Flash Point ]:
86.2±14.8 °C
[ Exact Mass ]:
137.003220
[ PSA ]:
23.79000
[ LogP ]:
2.20
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.563
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DI2800000
- CHEMICAL NAME :
- Benzonitrile, p-chloro-
- CAS REGISTRY NUMBER :
- 623-03-0
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C7-H4-Cl-N
- MOLECULAR WEIGHT :
- 137.57
- WISWESSER LINE NOTATION :
- NCR DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,908,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,906,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H332-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R20/22;R36/37/38
[ Safety Phrases ]:
S23-S26-S36
[ RIDADR ]:
3439
[ WGK Germany ]:
2
[ RTECS ]:
DI2800000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
29269095
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Appl. Microbiol. Biotechnol. 73(3) , 567-75, (2006)
Aspergillus niger K10 cultivated on 2-cyanopyridine produced high levels of an intracellular nitrilase, which was partially purified (18.6-fold) with a 24% yield. The N-terminal amino acid sequence of...