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Quinfamide

Names

[ CAS No. ]:
62265-68-3

[ Name ]:
Quinfamide

[Synonym ]:
1-(dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl 2-furoate
Quinfamido [INN-Spanish]
Quinfamide
Quinfamidum [INN-Latin]
1-(dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline
EINECS 263-478-1
Amenide

Biological Activity

[Description]:

Quinfamide is an antiamebic agent. Quinfamide can be used to treat tropical parasitic infections such as Amoebiasis and Helminthiasis[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite
Research Areas >> Infection

[References]

[1]. Davila-Gutierrez CE, et al. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg. 2002 Mar;66(3):251-4.

Chemical & Physical Properties

[ Density]:
1.428g/cm3

[ Boiling Point ]:
551.3ºC at 760mmHg

[ Melting Point ]:
145-146ºC

[ Molecular Formula ]:
C16H13Cl2NO4

[ Molecular Weight ]:
354.18

[ Flash Point ]:
287.2ºC

[ Exact Mass ]:
353.02200

[ PSA ]:
59.75000

[ LogP ]:
3.64670

[ Index of Refraction ]:
1.599

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LU0215000
CHEMICAL NAME :
2-Furancarboxylic acid, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl ester
CAS REGISTRY NUMBER :
62265-68-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H13-Cl2-N-O4
MOLECULAR WEIGHT :
354.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,599,1979
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,599,1979

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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