m-PEG4-NHS ester

Names

[ Name ]:
m-PEG4-NHS ester

[Synonym ]:
N-Succinimidyl 4,7,10,13-Tetraoxatetradecanoate
1-[(14-Oxo-2,5,8,11-tetraoxatetradecan-14-yl)oxy]-2,5-pyrrolidinedione
Methyl-PEG4-NHS Ester
4,7,10,13-Tetraoxatetradecanoic Acid N-Succinimidyl Ester
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13-tetraoxatetradec-1-yl)oxy]-
AmbotzPEG1880
1-(4,7,10,13-tetraoxatetradecan-1-oyloxy)pyrrolidine-2,5-dione
N-hydroxysuccinimidyl 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propanoate
M2186

Biological Activity

[Description]:

m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
431.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₃NO₈

[ Molecular Weight ]:
333.334

[ Flash Point ]:
214.9±31.5 °C

[ Exact Mass ]:
333.142365

[ PSA ]:
100.60000

[ LogP ]:
-2.87

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.490

[ Storage condition ]:
-20°C

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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