4-Ethoxyphenol

Names

[ CAS No. ]:
622-62-8

[ Name ]:
4-Ethoxyphenol

[Synonym ]:
Phenol,p-ethoxy
p-ethoxylphenol
4-Hydroxyphenetole
Phenol,4-ethoxy
1-hydroxy-4-ethoxybenzene
P-ETHOXYPHENOL
4-Ethoxybenzolol
EINECS 210-748-1
Hydroquinone monoethyl ether
4-Ethoxyphenol
Phenol, 4-ethoxy-
4-(ethyloxy)phenol
p-Hydroxyphenetole
MFCD00002334
4-ethoxy-phenol
Ethoxyphenol,p

Biological Activity

[Description]:

4-Ethoxyphenol is an endogenous metabolite.

[Related Catalog]:

Research Areas >> Metabolic Disease

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
246.4±13.0 °C at 760 mmHg

[ Melting Point ]:
64-67 °C

[ Molecular Formula ]:
C₈H₁₀O₂

[ Molecular Weight ]:
138.164

[ Flash Point ]:
124.0±4.8 °C

[ Exact Mass ]:
138.068085

[ PSA ]:
29.46000

[ LogP ]:
1.84

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL3790000

CHEMICAL NAME :: Phenol, p-ethoxy-

CAS REGISTRY NUMBER :: 622-62-8

BEILSTEIN REFERENCE NO. :: 1907114

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H10-O2

MOLECULAR WEIGHT :: 138.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6. Volume(issue)/page/year: 22,1,1952 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 667 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R37/38;R41

[ Safety Phrases ]:
S37/39-S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
SL3790000

[ HS Code ]:
2909500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

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Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Microperoxidase/H2O2-mediated alkoxylating dehalogenation of halophenol derivatives in alcoholic media.

Proc. Natl. Acad. Sci. U. S. A. 94(9) , 4295-9, (1997)

The results of this study report the H2O2-driven microperoxidase-8 (MP8)-catalyzed dehalogenation of halophenols such as 4-fluorophenol, 4-chlorophenol, 4-bromophenol, and 2-fluorophenol in alcoholic ...