Methyl-PEG4-acyl chloride

Names

[ Name ]:
Methyl-PEG4-acyl chloride

[Synonym ]:
tetraethylene glycol monomethyl ether chloroformate
Carbonochloridic acid,3,6,9,12-tetraoxatridec-1-yl ester
2-{2-[2-(2-methoxyethoxy)-ethoxy]ethoxy}ethyl chloroformate
Methyl-PEG4-acyl chloride

Biological Activity

[Description]:

Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₉ClO₆

[ Molecular Weight ]:
270.70700

[ Exact Mass ]:
270.08700

[ PSA ]:
63.22000

[ LogP ]:
1.05800

Synthetic Route

Click to get detail synthetic route

Related Compounds

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