morphine sulfate pentahydrate
Names
[ CAS No. ]:
6211-15-0
[ Name ]:
morphine sulfate pentahydrate
[Synonym ]:
levo-morphine sulfate
Kadian (tn)
(-)-morphine sulfate
Astramor ph (tn)
morphin sulfate
Morphine sulfate hydrate
Depodur (tn)
MORPHINESULFATE,USP
Depodur
morphine sulphate
Astramor ph
Avinza (tn)
Morphia Sulfate Hydrate
Chemical & Physical Properties
[ Boiling Point ]:
476.2ºC at 760 mmHg
[ Melting Point ]:
>240ºC (dec.)
[ Molecular Formula ]:
C34H50N2O15S
[ Molecular Weight ]:
758.83000
[ Flash Point ]:
241.8ºC
[ Exact Mass ]:
758.29300
[ PSA ]:
234.99000
[ LogP ]:
2.37850
[ Storage condition ]:
Controlled Substance, -20°C Freezer
[ Water Solubility ]:
ethanol: 1.8 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC8760000
- CAS REGISTRY NUMBER :
- 6211-15-0
- LAST UPDATED :
- 199507
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C34-H38-N2-O6.H2-O4-S.5H2-O
- MOLECULAR WEIGHT :
- 758.92
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 973 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7173 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22
[ Safety Phrases ]:
22-36
[ RIDADR ]:
UN 1544 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
QC8760000
Articles
J. Pharmacol. Exp. Ther. 352(3) , 462-70, (2015)
Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug...
Catalytic enantioselective synthesis of quaternary carbon stereocentres.Nature 516(7530) , 181-91, (2014)
Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catal...
Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.Br. J. Anaesth. 113(6) , 964-9, (2014)
Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery. We thus aimed to assess the absorption and safety of entera...