CCG-63802

Names

[ CAS No. ]:
620112-78-9

[ Name ]:
CCG-63802

[Synonym ]:
unii-339bu4y35u
hms1804i11
CCG-63802

Biological Activity

[Description]:

CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4.IC50 value:Target: RGSCCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> RGS Protein

Research Areas >> Cancer

[References]

[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.

[2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

[3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

[Related Small Molecules]

CCG 203769 | CCG-63808

Chemical & Physical Properties

[ Density]:
1.31

[ Boiling Point ]:
547.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₁₈N₄O₂S

[ Molecular Weight ]:
450.51200

[ Flash Point ]:
285.1ºC

[ Exact Mass ]:
450.11500

[ PSA ]:
108.52000

[ LogP ]:
5.77748

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8℃

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.