(D-Trp8,D-Cys14)-Somatostatin-14

Names

[ CAS No. ]:
61950-59-2

[ Name ]:
(D-Trp8,D-Cys14)-Somatostatin-14

[Synonym ]:
1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaconta-5,8,11,17,20,23,26,29,32,35-decaene-4-carboxylic acid, 19,34-bis(4-aminobutyl)-6,9,12,18,21,24,27,30,33,36-decahydroxy-10-[(1R)-1-hydroxyethyl]-31-(2-hydroxy-2-iminoethyl)-7-(hydroxymethyl)-37-[[1-hydroxy-2-(methylamino)ethylidene]amino]-22-(1H-indol-3-ylmethyl)-15-oxo-13,25,28-tris(phenylmethyl)-, (4S,7S,8E,10S,13S,17E,19S,22R,25S,28S,31S,34S,35E,37R)-
(4S,7S,8E,10S,13S,17E,19S,22R,25S,28S,31S,34S,35E,37R)-19,34-Bis(4-aminobutyl)-13,25,28-tribenzyl-6,9,12,18,21,24,27,30,33,36-decahydroxy-10-[(1R)-1-hydroxyethyl]-31-(2-hydroxy-2-iminoethyl)-7-(hydroxymethyl)-37-{[1-hydroxy-2-(methylamino)ethylidene]amino}-22-(1H-indol-3-ylmethyl)-15-oxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaconta-5,8,11,17,20,23,26,29,32,35-decaene-4-carboxylic acid

Biological Activity

[Description]:

(D-Trp8,D-Cys14)-Somatostatin-14 is a Somatostatin synthetic analogue. (D-Trp8,D-Cys14)-Somatostatin-14 can be used for the research of metabolic related diseases[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

(D-Trp8,D-Cys14)-Somatostatin-14 (12 μg/100g; i.p.) 不改变仓鼠肠道碳水化合物的体内吸收，但抑制雌性动物刷状缘乳糖酶活性[2]。

[References]

[1]. Vécsei L, et, al. Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats. Psychoneuroendocrinology. 1986;11(1):111-5.

[2]. Martínez-Sapiña J, et, al. Somatostatin and its analogue (D-Trp8,D-Cys14)-somatostatin do not modify intestinal absorption in vivo of carbohydrates in hamster intestine, but they do modify some disaccharidases. Q J Exp Physiol. 1989 Nov;74(6):851-6.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₇₆H₁₀₄N₁₈O₁₉S₂

[ Molecular Weight ]:
1536.774

[ Exact Mass ]:
1535.668945

[ PSA ]:
663.83000

[ LogP ]:
-6.45

[ Index of Refraction ]:
1.681

Related Compounds

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