Amfenac Sodium Monohydrate

Names

[ Name ]:
Amfenac Sodium Monohydrate

[Synonym ]:
Sodium (2-amino-3-benzoylphenyl)acetate hydrate (1:1:1)
Amfenac sodium salt monohydrate
2-Amino-3-benzoylbenzeneacetic acid,monosodium salt,monohydrate
2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate
sodium,2-(2-amino-3-benzoylphenyl)acetate,hydrate
Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, hydrate (1:1:1)
AHR-5850D
Amfenac Sodium Hydrate
Amfenac sodium monohydrate
Fenazox
Amfenac sodium salt hydrate

Biological Activity

[Description]:

Amfenac Sodium Hydrate is a COX-2 inhibitor.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

COX-2

[In Vitro]

Cells transfected to express COX-2 have a higher proliferation rate than those do not. The addition of Amfenac Sodium Hydrate significantly decreases the proliferation rate of all cell lines. Nitric oxide production by macrophages is inhibited by the addition of melanoma conditioned medium, the addition of Amfenac Sodium Hydrate partially overcomes this inhibition[1]. Results show that Amfenac Sodium Hydrate inhibits the release of B-glucuronidase: 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[2].

[Cell Assay]

Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1].

[References]

[1]. Marshall JC, et al. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog. 2007 Nov 27;6:17.

[2]. Matsumoto T, et al. Effect of a non-steroidal anti-inflammatory drug (amfenac sodium) on polymorphonuclear leukocytes. Pharmacol Res Commun. 1982 Jun;14(6):523-32.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
520ºC at 760 mmHg

[ Melting Point ]:
242-244ºC

[ Molecular Formula ]:
C₁₅H₁₄NNaO₄

[ Molecular Weight ]:
295.266

[ Flash Point ]:
268.3ºC

[ Exact Mass ]:
295.082062

[ PSA ]:
92.45000

[ LogP ]:
1.30910

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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