Citraconic anhydride
Names
[ CAS No. ]:
616-02-4
[ Name ]:
Citraconic anhydride
[Synonym ]:
EINECS 210-459-0
3-methylfuran-2,5-dione
MFCD00005522
Chemical & Physical Properties
[ Density]:
1.247 g/mL at 25 °C(lit.)
[ Boiling Point ]:
213-214 °C(lit.)
[ Melting Point ]:
6-10 °C(lit.)
[ Molecular Formula ]:
C5H4O3
[ Molecular Weight ]:
112.08300
[ Flash Point ]:
215 °F
[ Exact Mass ]:
112.01600
[ PSA ]:
43.37000
[ LogP ]:
0.01610
[ Vapour density ]:
4 (vs air)
[ Index of Refraction ]:
n20/D 1.471(lit.)
[ Storage condition ]:
Store at RT.
[ Water Solubility ]:
decomposes
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GE6825000
- CHEMICAL NAME :
- Citraconic anhydride
- CAS REGISTRY NUMBER :
- 616-02-4
- BEILSTEIN REFERENCE NO. :
- 0001835
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H4-O3
- MOLECULAR WEIGHT :
- 112.09
- WISWESSER LINE NOTATION :
- T5VOVJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 218 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H311-H314-H317-H334-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R24;R34;R42/43
[ Safety Phrases ]:
S26-S36/37/39-S45-S28A
[ RIDADR ]:
UN 2810 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
GE6825000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
29171990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2917190090
[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
PLoS ONE 9(9) , e106255, (2014)
A recently developed matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) method to spatially profile the location and distribution of multiple N-linked glycan species in ...
Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery.Int. J. Pharm. 471(1-2) , 28-36, (2014)
A novel pH-sensitive polymeric micelle was reported. Methoxy poly(ethylene glycol)-b-poly(ϵ-caprolactone) copolymer with citraconic amide as pH-sensitive bond was synthesized (mPEG-pH-PCL). The copoly...
Pre-cultivation of adipose tissue-derived microvascular fragments in porous scaffolds does not improve their in vivo vascularisation potential.Eur. Cell. Mater. 29 , 190-200; discussion 200-1, (2015)
Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several...